Derek A Persons Selected Research

gamma-Globins

9/2010	Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model.
6/2009	Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
2/2009	Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
10/2004	Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia.
5/2003	Development of gene therapy for hemoglobin disorders.
3/2003	The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number.

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Derek A Persons Research Topics

Disease

16	Sickle Cell Anemia (Hemoglobin S Disease) 05/2015 - 03/2003
13	beta-Thalassemia (Cooley's Anemia) 03/2011 - 03/2003
6	Thalassemia 01/2017 - 05/2003
5	Anemia 01/2017 - 02/2009
2	Acute Erythroblastic Leukemia (Erythroleukemia) 06/2016 - 11/2007
2	Pneumococcal Infections 02/2012 - 02/2010
2	Inflammation (Inflammations) 09/2010 - 02/2010
2	Vesicular Stomatitis 07/2010 - 03/2002
1	Leukocytosis (Pleocytosis) 02/2012
1	Pneumococcal Pneumonia 02/2012
1	Sepsis (Septicemia) 02/2012
1	Leukocyte adhesion deficiency type 1 06/2011
1	Bacterial Infections (Bacterial Infection) 06/2011
1	Thrombophilia 09/2010
1	Hemolytic Anemia 09/2010
1	Feline Leukemia 07/2010
1	Polycythemia (Erythrocytosis) 01/2006
1	HIV Infections (HIV Infection) 06/2004

Drug/Important Bio-Agent (IBA)

10	Fetal Hemoglobin (Hemoglobin F)IBA 01/2017 - 03/2003
9	GlobinsIBA 01/2017 - 07/2003
6	Hemoglobins (Hemoglobin)IBA 03/2011 - 05/2003
6	gamma-GlobinsIBA 09/2010 - 03/2003
3	Hydroxyurea (Hydrea)FDA LinkGeneric 02/2012 - 02/2009
3	Proteins (Proteins, Gene)FDA Link 10/2010 - 03/2002
3	beta-Globins (beta Globin)IBA 08/2010 - 10/2004
2	Therapeutic UsesIBA 08/2010 - 01/2009
1	Transcription Factors (Transcription Factor)IBA 06/2016
1	IronIBA 01/2015
1	E-SelectinIBA 02/2012
1	IntegrinsIBA 06/2011
1	alpha-GlobinsIBA 10/2010
1	Green Fluorescent ProteinsIBA 07/2010
1	Viral Envelope ProteinsIBA 07/2010
1	Glycoproteins (Glycoprotein)IBA 07/2010
1	CholesterolIBA 02/2010
1	PerforinIBA 02/2010
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 02/2010
1	Messenger RNA (mRNA)IBA 02/2009
1	Erythropoietin Receptors (Erythropoietin Receptor)IBA 01/2006
1	CytokinesIBA 06/2004

Therapy/Procedure

4	Therapeutics 11/2012 - 02/2009
1	Stem Cell Transplantation 08/2010
1	Transplantation 01/2009